On a mathematical model of tumor-immune system interactions with an oncolytic virus therapy

<p style='text-indent:20px;'>We investigate a mathematical model of tumor–immune system interactions with oncolytic virus therapy (OVT). Susceptible tumor cells may become infected by viruses that are engineered specifically to kill cancer but not healthy cells. Once the destroyed oncolysis, they release new infectious particles help surrounding The immune constructed includes innate and adaptive immunities while immunity is further separated into anti-viral or anti-tumor first analyzed studying boundary equilibria their stability. Numerical bifurcation analysis performed outcomes therapy. has unique remission equilibrium, which unlikely be stable based on parameter values given in literature. Multiple positive sizes close carrying capacity coexist if less antigenic. However, as viral infection rate increases, OVT becomes more effective sense can dormant for longer period time even when weakly antigenic.</p>